Description

5,6,7,8-Tetrahydropyrido[3,4-C]Pyridazin-3(2H)-One Hydrochloride is a high-purity pharmaceutical intermediate and research chemical of significant interest in modern drug discovery. This compound serves as a critical building block for the synthesis of novel therapeutic agents, particularly in the development of central nervous system (CNS) and oncology-related pharmaceuticals. It is essential for medicinal chemistry research, process development, and scale-up manufacturing within the global pharmaceutical and biotechnology sectors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potent and selective drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used extensively in hit-to-lead optimization and structure-activity relationship (SAR) studies for novel bioactive molecules.
• CNS Drug Development: Serves as a core scaffold for compounds being investigated for neurological and psychiatric disorders.
• Oncology Research: Employed in the design and synthesis of potential kinase inhibitors and other targeted cancer therapies.
• Process Chemistry & Scale-Up: Critical for route scouting, process optimization, and cGMP manufacturing of active pharmaceutical ingredients (APIs).
• Biochemical Tool Compound: Used in vitro and in vivo to study specific biological mechanisms and validate novel targets.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services.

Basic Information

Product Name	5,6,7,8-Tetrahydropyrido[3,4-C]Pyridazin-3(2H)-One Hydrochloride
CAS No.	1820707-50-3
Molecular Formula	C8H10N3O·HCl
Molecular Weight	201.64 g/mol (Free base: 165.19 g/mol)
Synonyms	5,6,7,8-Tetrahydro-3(2H)-pyrido[3,4-c]pyridazinone hydrochloride; 2,3,5,6,7,8-Hexahydropyrido[3,4-c]pyridazin-1-one hydrochloride; 3-Oxo-2,3,5,6,7,8-hexahydropyrido[3,4-c]pyridazine hydrochloride; THPP Hydrochloride; Pyridopyridazinone hydrochloride derivative
EINECS	Contact for details

Quality Control

Our 5,6,7,8-Tetrahydropyrido[3,4-C]Pyridazin-3(2H)-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under anhydrous conditions to maintain product integrity and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.