Description

S-Acetyl-Peg2-T-Butyl Ester is a high-purity, functionalized polyethylene glycol (PEG) derivative used as a key building block in advanced organic synthesis and bioconjugation. This compound is essential for researchers and manufacturers requiring precise, reproducible linker chemistry for creating complex molecular architectures. It is particularly valuable for the development of pharmaceutical intermediates, prodrugs, and novel drug delivery systems where controlled release and targeted action are critical.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs) and prodrugs, enabling enhanced solubility and bioavailability.
• Bioconjugation & Linker Chemistry: Serves as a versatile heterobifunctional linker for attaching therapeutic payloads (e.g., drugs, toxins, imaging agents) to antibodies, proteins, or peptides in ADC (Antibody-Drug Conjugate) and targeted therapy development.
• Polymer & Material Science: Used to modify polymer backbones, introducing functional handles for further chemical modification to create smart materials, hydrogels, and surface coatings.
• Proteomics Research: Employed as a tool compound for protein labeling and modification studies, facilitating structure-activity relationship (SAR) analysis.
• Diagnostic Reagent Synthesis: Acts as a building block for constructing contrast agents and molecular probes used in diagnostic imaging (e.g., MRI, fluorescence).
• Cross-linking Agent: Utilized in the preparation of cross-linked biomaterials and matrices for controlled release applications and tissue engineering scaffolds.

Basic Information

Product Name	S-Acetyl-Peg2-T-Butyl Ester
CAS No.	1820641-93-7
Molecular Formula	C13H24O6S
Molecular Weight	308.39 g/mol
Synonyms	2,5,8,11-Tetraoxatetradecan-14-oic acid, 13-acetyl-12-mercapto-, 1,1-dimethylethyl ester; 1-tert-Butyl 13-acetyl 12-mercapto-2,5,8,11-tetraoxatetradecanedioate; S-Acetyl-PEG2-t-butyl ester; tert-Butyl 13-acetyl-12-mercapto-2,5,8,11-tetraoxatetradecanedioate; Acetyl-PEG2-SH t-butyl ester; S-Acetyl-3,6-dioxaoctane-1,8-dioic acid 1-tert-butyl ester; Heterobifunctional PEG linker, acetyl-PEG2-tBu ester
EINECS	Contact for details

Quality Control

Our S-Acetyl-Peg2-T-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support cGMP-grade production for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.