Description

S-Acetyl-Peg6-Tos is a bifunctional polyethylene glycol (PEG) derivative featuring a terminal acetyl-protected hydroxyl group and a tosylate leaving group. This molecular architecture makes it a highly versatile and reactive intermediate for constructing sophisticated chemical architectures, particularly in pharmaceutical and bioconjugation applications. It is essential for researchers and manufacturers in the fields of bioconjugation, prodrug development, and advanced material science who require reliable, high-purity linkers for precise molecular assembly.

Application

• Bioconjugation Linker: Used to attach drugs, dyes, or other functional molecules to proteins, antibodies, or peptides, enhancing solubility and pharmacokinetics.
• Prodrug Synthesis: Serves as a key building block for creating prodrugs with controlled release mechanisms via enzymatic cleavage of the acetyl group.
• Polymer Chemistry: Acts as a functional initiator or monomer for synthesizing tailored PEG-based polymers and hydrogels with specific end-group functionality.
• Chemical Probe Development: Utilized in the synthesis of probes for biological imaging and diagnostic assays due to its water-solubilizing PEG spacer.
• ADC (Antibody-Drug Conjugate) Payload Attachment: Facilitates the site-specific conjugation of cytotoxic payloads to antibodies in ADC manufacturing.
• Surface Functionalization: Employed to modify nanoparticles, biosensors, or other material surfaces with reactive tosylate groups for further coupling.

Basic Information

Product Name	S-Acetyl-Peg6-Tos
CAS No.	1818294-25-5
Molecular Formula	C25H42O11S
Molecular Weight	550.67 g/mol
Synonyms	1-{2-[2-(2-{2-[2-(2-Acetoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethyl} 4-methylbenzenesulfonate; Acetyl-PEG6-OTs; S-Acetyl-PEG6-tosylate; 2,5,8,11,14,17-Hexaoxanonadecan-19-yl acetate, 1-(4-methylbenzenesulfonate); Acetyl-PEG6-Tosylate; PEG6-Acetate Tosylate; 19-Acetoxy-3,6,9,12,15-pentaoxa-18-azanonadecyl 4-methylbenzenesulfonate (related structure); Tos-PEG6-OAc
EINECS	Contact for details

Quality Control

Our S-Acetyl-Peg6-Tos is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent moisture absorption and degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.