Description

Amino-Peg3-Sulfonic Acid is a specialized bifunctional PEG linker featuring a primary amine and a sulfonic acid group, separated by a triethylene glycol spacer. This unique structure is critical for creating stable, water-soluble conjugates and modifying biomolecules to enhance their solubility and pharmacokinetic properties. It is an essential building block for researchers and manufacturers in pharmaceutical development, bioconjugation, and advanced material science, particularly for drug delivery systems and diagnostic agents.

Application

• Bioconjugation and Linker Chemistry: Used to covalently link peptides, proteins, or antibodies to drugs, dyes, or solid surfaces, improving aqueous solubility.
• ADC (Antibody-Drug Conjugate) Development: Serves as a hydrophilic spacer in linker-payload constructs to modulate drug loading and conjugate stability.
• Surface Functionalization: Modifies nanoparticles, quantum dots, or biosensor surfaces to introduce amine or sulfonate groups for further coupling or to enhance biocompatibility.
• Polymer and Dendrimer Synthesis: Acts as a monomer or modifying agent to create functional, water-soluble polymers with tailored charge characteristics.
• Prodrug Design: Facilitates the attachment of therapeutic agents to solubilizing PEG-sulfonate chains for improved bioavailability.
• Chemical Biology Probes: Utilized in synthesizing probes for studying protein interactions and cellular localization due to its polar, non-fouling PEG chain.

Basic Information

Product Name	Amino-Peg3-Sulfonic Acid
CAS No.	1817735-43-5
Molecular Formula	C8H19NO6S
Molecular Weight	257.30 g/mol
Synonyms	2,5,8,11-Tetraoxatridecan-13-amine, 13-sulfonic acid; 3,6,9-Trioxa-12-azatetradecane-1-sulfonic acid, 14-amine; 15-Amino-4,7,10-trioxa-13-thiapentadecanoic acid 13-oxide; Amino-PEG3-sulfonic acid; NH2-PEG3-SO3H; 1-Amino-3,6,9-trioxa-12-thiadodecane 12,12-dioxide; PEG3 amine sulfonic acid; 11-Amino-3,6,9-trioxa-11-azatetradecane-1-sulfonic acid
EINECS	Contact for details

Quality Control

Every batch of Amino-Peg3-Sulfonic Acid is manufactured under a quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and appearance. Our quality commitment supports applications in GMP-grade intermediate synthesis and research where traceability and reliability are paramount.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.