Description

(R)-6-(Trifluoromethoxy)Chroman-4-Amine Hydrochloride is a high-purity chiral amine building block and pharmaceutical intermediate. This compound is valued for its structural motif, which is crucial for imparting metabolic stability and modulating physicochemical properties in active pharmaceutical ingredients. It is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutics, particularly in central nervous system (CNS) and cardiovascular disease areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially those targeting serotonin and adrenergic receptors.
• Asymmetric Synthesis: Used as a chiral amine precursor or resolving agent in the preparation of enantiomerically pure compounds.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Chemical Biology: Can be utilized as a probe or ligand in the study of biological targets and pathways.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for advanced pharmaceutical intermediates.

Basic Information

Product Name	(R)-6-(Trifluoromethoxy)Chroman-4-Amine Hydrochloride
CAS No.	1810074-61-3
Molecular Formula	C10H11F3NO2·HCl
Molecular Weight	269.66 (Free base) / 306.12 (HCl salt)
Synonyms	(R)-6-(Trifluoromethoxy)-3,4-dihydro-2H-chromen-4-amine hydrochloride; (R)-4-Amino-6-(trifluoromethoxy)chroman hydrochloride; (R)-6-(Trifluoromethoxy)-3,4-dihydro-2H-1-benzopyran-4-amine hydrochloride; (R)-TFA-Chroman-4-Amine HCl; (R)-TFMO-Chroman-4-Amine Hydrochloride; (R)-enantiomer of 6-(Trifluoromethoxy)chroman-4-amine HCl
EINECS	Contact for details

Quality Control

Our (R)-6-(Trifluoromethoxy)Chroman-4-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.