Description

Thp-Ss-Peg1-Tos CAS NO 1807512-37-3 is a specialized bifunctional linker molecule containing a tetrahydropyranyl (THP) protecting group, a disulfide (SS) bridge, a polyethylene glycol (PEG) spacer, and a tosylate (Tos) leaving group. This unique structure makes it a critical intermediate for the controlled synthesis and bioconjugation of complex molecules, particularly in the development of targeted therapeutics and advanced drug delivery systems. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require high-purity, functionalized building blocks for creating prodrugs, antibody-drug conjugates (ADCs), and stimuli-responsive polymers.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel prodrugs and targeted cancer therapies, where the disulfide bond enables glutathione-mediated release in tumor cells.
• Bioconjugation Reagent: Used for the site-specific modification of proteins, peptides, and antibodies, facilitating the creation of stable yet cleavable linkages in antibody-drug conjugates (ADCs).
• Polymer Chemistry: Serves as a functional monomer or cross-linker for synthesizing smart, stimuli-responsive hydrogels and nanomaterials that degrade under reductive conditions.
• Prodrug Design: Enables the development of prodrugs where the active pharmaceutical ingredient (API) is masked by the THP group and linked via a redox-sensitive disulfide bond for controlled activation.
• Chemical Biology Tool: Employed in research for studying cellular uptake, intracellular trafficking, and redox biology due to its cleavable disulfide linker and PEGylated structure.
• Material Science: Used in the fabrication of functional surfaces and coatings where a controlled, on-demand release of an attached moiety is required.

Basic Information

Product Name	Thp-Ss-Peg1-Tos
CAS No.	1807512-37-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	2-({2-[2-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy}ethyl) 4-methylbenzenesulfonate; Tetrahydropyranyl disulfide PEG1 tosylate; THP-protected SS-PEG1-OTs; 1-(2-{2-[2-(4-Methylphenyl)sulfonyloxy]ethoxy}ethoxy)ethyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate (related structure); Tos-PEG1-SS-THP; PEGylated disulfide linker with tosylate and THP; Redox-cleavable PEG linker
EINECS	Contact for details

Quality Control

Our Thp-Ss-Peg1-Tos is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, NMR for structural confirmation, and mass spectrometry for identity verification, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and maintain long-term stability. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents and reducing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.