Description

Thp-Ss-Peg1-T-Butyl Ester CAS NO 1807503-88-3 is a specialized bifunctional chemical building block featuring a tert-butyl ester group and a THP (tetrahydropyranyl) protected moiety, linked by a short polyethylene glycol (PEG) spacer. This compound is engineered for high-value applications in pharmaceutical research and advanced material science, where precise molecular architecture and functional group compatibility are critical. It serves as a key intermediate for medicinal chemists and process development scientists in the synthesis of complex molecules, including active pharmaceutical ingredients (APIs), prodrugs, and functional polymers.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of novel drug candidates, particularly where controlled release or solubility enhancement is required.
• Prodrug Synthesis: Utilized for constructing prodrug linkers, leveraging the cleavable THP and ester groups for targeted drug delivery systems.
• Peptide & Conjugate Chemistry: Serves as a versatile spacer or protecting group strategy in the synthesis of peptide-drug conjugates (PDCs) and antibody-drug conjugates (ADCs).
• Polymer & Material Science: Acts as a functional monomer or cross-linking agent for creating smart polymers, hydrogels, and surface-modified materials with tailored properties.
• Chemical Biology Probes: Used in the development of molecular probes and tags for studying biological processes and diagnostics.
• Process Chemistry & Scale-up: Provides a reliable and scalable intermediate for optimizing manufacturing routes for complex organic molecules under GMP conditions.

Basic Information

Product Name	Thp-Ss-Peg1-T-Butyl Ester
CAS No.	1807503-88-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1-(1,3-Dithian-2-yl)-2-[2-(2-tetrahydropyranyloxy)ethoxy]ethyl 2,2-Dimethylpropanoate; 2,2-Dimethylpropanoic Acid 1-(1,3-Dithian-2-yl)-2-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]ethyl Ester; THP-SS-PEG1-t-Butyl Ester; t-Butyl Ester THP-SS-PEG1; SS-THP-PEG1-OtBu; tert-Butyl 2-(2-(tetrahydro-2H-pyran-2-yloxy)ethoxy)-1-(1,3-dithian-2-yl)ethyl carbonate (related structure); 1807503-88-3
EINECS	Contact for details

Quality Control

Every batch of Thp-Ss-Peg1-T-Butyl Ester is manufactured and tested under a strict quality management system. We employ advanced analytical techniques, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment. Our quality commitment supports applications requiring high-purity intermediates for research and development under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, it is recommended to keep the container under an inert atmosphere (e.g., nitrogen or argon) in a desiccator.

Specification

Item	Specification
Appearance	White to off-white solid or colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.