Description

4-Carboxymethylphenylalanine Hydrochloride is a high-purity, non-natural amino acid derivative designed for advanced research and pharmaceutical development. This compound serves as a critical building block in the synthesis of complex peptides and active pharmaceutical ingredients (APIs), where precise molecular structure is paramount. It is essential for researchers and manufacturers in the fields of medicinal chemistry, peptide synthesis, and drug discovery who require reliable, high-quality intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel peptide-based drugs and therapeutic agents.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce specific functionalized phenylalanine residues.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and the development of enzyme inhibitors or receptor ligands.
• Bioconjugation: The carboxymethyl group provides a handle for conjugation to other molecules, such as fluorescent dyes, polymers, or proteins.
• Chemical Biology Probes: Useful for creating labeled peptides or probes to study biological processes and protein interactions.
• API Development: Serves as a critical raw material in the development and scale-up of new active pharmaceutical ingredients.

Basic Information

Product Name	4-Carboxymethylphenylalanine Hydrochloride
CAS No.	1803572-24-8
Molecular Formula	C11H13NO4 • HCl
Molecular Weight	259.68 g/mol (Free base: 223.23 g/mol)
Synonyms	4-Carboxymethyl-L-phenylalanine HCl; (S)-2-Amino-3-(4-(carboxymethyl)phenyl)propanoic acid hydrochloride; Fmoc-Phe(4-CH2COOH)-OH (precursor); 4-(Carboxymethyl)-L-phenylalanine hydrochloride; 4-CM-Phe-OH • HCl; 4-Carboxymethylphenylalanine HCl Salt; 4-Carboxymethyl-DL-phenylalanine hydrochloride (racemic mixture)
EINECS	Contact for details

Quality Control

Our 4-Carboxymethylphenylalanine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and comprehensive identification tests. A Certificate of Analysis (COA) detailing all specifications and results is provided with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.