Description

Citric Acid (3-Methanethiosulfonate Ethyl Amide) is a specialized functionalized derivative of citric acid, designed for advanced chemical synthesis and bioconjugation applications. This compound is valued for its unique thiol-reactive methanethiosulfonate group, enabling precise and stable modifications to proteins, peptides, and other biomolecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for developing targeted therapeutics, probes, and high-value intermediates.

Application

• Bioconjugation Reagent: For site-specific modification of cysteine residues in proteins and antibodies to create antibody-drug conjugates (ADCs) or diagnostic probes.
• Pharmaceutical Intermediate: In the synthesis of novel active pharmaceutical ingredients (APIs) requiring a cleavable or stable linker with a carboxylic acid handle.
• Proteomics Research: As a tool compound for labeling, crosslinking, or affinity purification in biochemical and proteomic studies.
• Polymer Functionalization: To introduce reactive thiol groups or citric acid moieties onto polymer backbones for creating smart biomaterials.
• Surface Chemistry: For the functionalization of nanoparticles, biosensors, and other surfaces to enable specific biomolecular attachment.

Basic Information

Product Name	Citric Acid (3-Methanethiosulfonate Ethyl Amide)
CAS No.	1797099-42-3
Molecular Formula	C9H15NO8S2
Molecular Weight	329.35 g/mol
Synonyms	3-[(Ethylamino)thioxomethyl]thio-1,2,3-propanetricarboxylic acid; 1,2,3-Propanetricarboxylic acid, 2-[(ethylamino)thioxomethyl]thio-; Citric acid MTS ethyl amide; MTS-Citric Acid Ethyl Amide; Thiol-reactive citric acid derivative; S-(2-Carboxyethyl) citric acid thioester ethylamide; (2R,3S)-2-[(Ethylcarbamothioyl)thio]butane-1,2,3-tricarboxylic acid
EINECS	Contact for details

Quality Control

Our Citric Acid (3-Methanethiosulfonate Ethyl Amide) is manufactured under strict quality systems. Each batch is characterized and tested to ensure identity, purity, and consistency suitable for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (by titration)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.