Description

Cyclobutanecarboxylic Acid, 3-(Hydroxymethyl)-, cis- is a high-purity, chiral building block of significant interest in advanced organic synthesis. Its unique cis-fused bicyclic structure, featuring both carboxylic acid and hydroxymethyl functional groups, makes it a versatile precursor for constructing complex molecular architectures. This compound is particularly valuable for pharmaceutical R&D and fine chemical manufacturing, where it serves as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and specialty materials.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new therapeutic agents, particularly in medicinal chemistry programs.
• Asymmetric Synthesis: Used as a starting material or building block in stereoselective synthesis to introduce the cis-cyclobutane scaffold into target molecules.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing novel chiral ligands and organocatalysts used in enantioselective transformations.
• Material Science Research: Employed in the synthesis of specialty polymers or functional materials with tailored properties derived from the strained cyclobutane ring.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and protein interactions.
• Academic & Industrial R&D: A valuable compound for methodological research in organic chemistry and process development in fine chemical industries.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 3-(Hydroxymethyl)-, cis-
CAS No.	1783662-84-9
Molecular Formula	C6H10O3
Molecular Weight	130.14 g/mol
Synonyms	cis-3-(Hydroxymethyl)cyclobutanecarboxylic Acid; (1s,3s)-3-(Hydroxymethyl)cyclobutanecarboxylic Acid; rel-(1R,3R)-3-(Hydroxymethyl)cyclobutanecarboxylic Acid; 3-Hydroxymethyl-cyclobutanecarboxylic Acid, cis-; cis-3-Carboxycyclobutylmethanol; Bicyclo[2.1.0]pentane-1-carboxylic acid, 3-hydroxymethyl-, cis-
EINECS	Contact for details

Quality Control

Our Cyclobutanecarboxylic Acid, 3-(Hydroxymethyl)-, cis- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.