Description

3-Chloro-2-Fluoro-4-Methoxyphenol is a high-purity, multi-functional halogenated phenolic compound of significant interest in advanced organic synthesis. Its unique substitution pattern makes it a valuable and versatile building block for the development of complex molecules. This intermediate is primarily utilized by research and development chemists and process engineers in the pharmaceutical and agrochemical industries.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring halogenated aromatic scaffolds.
• Agrochemical Synthesis: Serves as a precursor in the development of novel herbicides, fungicides, and pesticides, leveraging its halogen and methoxy functional groups.
• Liquid Crystal & OLED Material Research: Used in the research and development of advanced electronic materials due to its polarizable aromatic structure.
• Polymer Modification: Acts as a monomer or functionalization agent for creating specialty polymers with specific thermal or chemical resistance properties.
• Dye & Pigment Intermediate: Employed in the synthesis of complex colorants and functional dyes.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki-Miyaura and Buchwald-Hartwig amination to construct biaryl systems.

Basic Information

Product Name	3-Chloro-2-Fluoro-4-Methoxyphenol
CAS No.	1781486-60-9
Molecular Formula	C7H6ClFO2
Molecular Weight	176.57 g/mol
Synonyms	3-Chloro-2-fluoro-4-methoxy-phenol; 2-Fluoro-3-chloro-4-methoxyphenol; 4-Methoxy-3-chloro-2-fluorophenol; Phenol, 3-chloro-2-fluoro-4-methoxy-; 1781486-60-9
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-Fluoro-4-Methoxyphenol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), identity confirmation (IR, NMR), and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and bases. The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.