Description

trans-3-(Hydroxymethyl)Cyclobutane-1-Carboxylic Acid is a high-purity, functionalized cyclobutane derivative of significant interest in advanced organic synthesis. This compound serves as a versatile and valuable chiral building block for the construction of complex molecular architectures. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in programs targeting central nervous system (CNS) disorders and metabolic diseases.
• Medicinal Chemistry: Used in lead optimization and structure-activity relationship (SAR) studies to introduce the constrained cyclobutane ring system, which can improve potency, selectivity, and metabolic stability.
• Agrochemical Synthesis: Employed as a building block in the development of novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or cross-linking agent for the synthesis of novel polymers with specific thermal or mechanical properties.
• Peptidomimetics: Incorporated into peptide analogs to confer rigidity and explore novel bioactive conformations.

Basic Information

Product Name	trans-3-(Hydroxymethyl)Cyclobutane-1-Carboxylic Acid
CAS No.	1781036-60-9
Molecular Formula	C6H10O3
Molecular Weight	130.14 g/mol
Synonyms	(1r,3r)-3-(Hydroxymethyl)cyclobutane-1-carboxylic acid; trans-3-(Hydroxymethyl)cyclobutanecarboxylic acid; (1R,3R)-3-(Hydroxymethyl)cyclobutanecarboxylic acid; rel-(1R,3R)-3-(Hydroxymethyl)cyclobutanecarboxylic Acid; Cyclobutanecarboxylic acid, 3-(hydroxymethyl)-, (1R,3R)-rel-; (1R,3R)-3-(Hydroxymethyl)-1-cyclobutanecarboxylic acid
EINECS	Contact for details

Quality Control

Our trans-3-(Hydroxymethyl)Cyclobutane-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and process development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.