Description

(3,3-Difluorotetrahydro-2H-Pyran-4-Yl)Methanamine is a high-value, fluorinated heterocyclic amine building block of significant interest in advanced organic synthesis. Its core value proposition lies in its unique molecular architecture, which incorporates both a pyran ring and difluoro motifs, enabling the modulation of physicochemical properties in target molecules. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the discovery and optimization of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in drug discovery programs, particularly for candidates targeting central nervous system (CNS) disorders, metabolic diseases, and infectious diseases.
• Agrochemical Research: Serves as a versatile scaffold for developing new herbicides, fungicides, and insecticides, where the fluorine atoms can enhance bioavailability and environmental stability.
• Ligand & Catalyst Development: Used in the synthesis of novel chiral ligands and organocatalysts for asymmetric synthesis applications.
• Material Science Precursor: Employed in the research of advanced polymers and functional materials, where its structure can impart specific electronic or surface properties.
• Medicinal Chemistry SAR Studies: Integral for structure-activity relationship (SAR) studies to explore the impact of a saturated, fluorinated heterocycle on potency and selectivity.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	(3,3-Difluorotetrahydro-2H-Pyran-4-Yl)Methanamine
CAS No.	1780537-28-1
Molecular Formula	C6H11F2NO
Molecular Weight	151.16 g/mol
Synonyms	4-(Aminomethyl)-3,3-difluorotetrahydro-2H-pyran; 3,3-Difluorotetrahydro-2H-pyran-4-methanamine; (3,3-Difluorotetrahydro-2H-pyran-4-yl)methylamine; 4-(Aminomethyl)-3,3-difluorotetrahydropyran; 3,3-Difluoro-4-(aminomethyl)tetrahydropyran; (Tetrahydro-3,3-difluoro-2H-pyran-4-yl)methanamine; 1780537-28-1; 4-Pyranmethanamine, tetrahydro-3,3-difluoro-
EINECS	Contact for details

Quality Control

Our (3,3-Difluorotetrahydro-2H-Pyran-4-Yl)Methanamine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality systems are designed to support cGMP and ISO standards for traceability and consistency, making it suitable for demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This amine compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.