Description

tert-Butyl ((3R,4R)-4-Hydroxytetrahydro-2H-Pyran-3-Yl)Carbamate is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic value. Its defined stereochemistry and protected functional groups make it a critical precursor in the synthesis of complex, biologically active molecules. This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical and fine chemical industries, particularly for projects involving carbohydrate mimetics, nucleoside analogs, and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially for antiviral and anticancer drug candidates.
• Protease Inhibitor Synthesis: Serves as a crucial scaffold in the development of protease inhibitors, leveraging its hydroxytetrahydro-2H-pyran structure.
• Carbohydrate Mimetic Chemistry: Used to create synthetic analogs of sugars and nucleosides for medicinal chemistry and biochemical research.
• Peptidomimetic Building Block: Incorporated into peptide-like chains to enhance metabolic stability and bioavailability of drug leads.
• Asymmetric Synthesis: Employed as a starting material or intermediate in stereoselective catalytic reactions to construct complex molecular architectures.
• Chemical Biology Research: Utilized as a tool compound or labeled precursor in probing biological pathways and enzyme mechanisms.

Basic Information

Product Name	tert-Butyl ((3R,4R)-4-Hydroxytetrahydro-2H-Pyran-3-Yl)Carbamate
CAS No.	1707290-11-6
Molecular Formula	C10H19NO4
Molecular Weight	217.26 g/mol
Synonyms	tert-Butyl N-[(3R,4R)-4-hydroxytetrahydro-2H-pyran-3-yl]carbamate; (3R,4R)-3-[(tert-Butoxycarbonyl)amino]tetrahydro-2H-pyran-4-ol; Boc-(3R,4R)-4-Hydroxytetrahydro-2H-pyran-3-yl-amine; (3R,4R)-4-Hydroxy-N-Boc-3-aminotetrahydropyran; (3R,4R)-3-(Boc-amino)tetrahydropyran-4-ol; BOC-4-Hydroxy-3-aminotetrahydropyran (3R,4R); tert-Butyl (3R,4R)-4-hydroxy-3-aminotetrahydropyran-1-carboxylate (non-standard)
EINECS	Contact for details

Quality Control

Our tert-Butyl ((3R,4R)-4-Hydroxytetrahydro-2H-Pyran-3-Yl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial methods for identity and assay, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.