Description

3-[(E)-(2-Chloro-6-Fluorophenyl)Methylidene]-2,3-Dihydro-4H-Chromen-4-One CAS NO 1705584-20-8 is a high-purity, synthetic organic compound belonging to the chromenone class, characterized by its distinct halogenated benzylidene structure. This compound serves as a critical advanced intermediate in modern chemical synthesis, enabling the development of novel molecular architectures. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in creating new active ingredients and functional materials.

Application

This chromenone derivative is a versatile building block with significant utility in research and industrial synthesis. Its primary and potential applications include:

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Research: Used in developing new active ingredients for crop protection products, leveraging its halogenated aromatic system.
• Material Science: Serves as a monomer or precursor for specialty polymers and organic electronic materials due to its conjugated chromenone core.
• Chemical Biology: Employed as a probe or scaffold in medicinal chemistry for structure-activity relationship (SAR) studies.
• Academic Research: Utilized in universities and institutes for methodological development in organic synthesis and heterocyclic chemistry.
• Dye & Pigment Intermediate: Potential starting material for synthesizing specialized chromophores and fluorophores.

Basic Information

Product Name	3-[(E)-(2-Chloro-6-Fluorophenyl)Methylidene]-2,3-Dihydro-4H-Chromen-4-One
CAS No.	1705584-20-8
Molecular Formula	C16H10ClFO2
Molecular Weight	288.70 g/mol
Synonyms	(E)-3-((2-Chloro-6-fluorobenzylidene)chroman-4-one; 3-[(2-Chloro-6-fluorophenyl)methylene]-2,3-dihydro-4H-1-benzopyran-4-one; 2H-1-Benzopyran-4-one, 3-[(2-chloro-6-fluorophenyl)methylene]-2,3-dihydro-; 3-(2-Chloro-6-fluorobenzylidene)chroman-4-one; Chromen-4-one, 3-[(E)-(2-chloro-6-fluorophenyl)methylene]-2,3-dihydro-; 1705584-20-8; Benzopyranone derivative
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for this advanced intermediate. Production follows current Good Manufacturing Practice (cGMP) principles where applicable, and every batch is analyzed using advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.