Description

Potassium (2-(4-(tert-Butoxycarbonyl)Piperazin-1-Yl)-3-Chloropyridin-4-Yl)Trifluoroborate is a high-value organotrifluoroborate salt, a critical building block in modern synthetic chemistry. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, enabling the efficient and precise construction of complex molecular architectures. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of novel active pharmaceutical ingredients (APIs) and advanced agrochemical intermediates.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent in the scalable production of complex drug candidates, particularly those containing piperazine and chloropyridine motifs.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, air- and moisture-tolerant organoboron reagent for forming carbon-carbon bonds under mild conditions.
• Agrochemical Research & Development: Used in constructing novel herbicide and fungicide molecules requiring specific heterocyclic frameworks.
• Material Science Precursor: Employed in the development of organic electronic materials and functional polymers.
• Peptidomimetic & PROTAC Molecule Construction: Facilitates the introduction of the Boc-protected piperazine fragment into complex bioactive molecules.
• Academic & Contract Research: A valuable tool for medicinal chemistry and process chemistry research in academic and CRO laboratories.

Basic Information

Product Name	Potassium (2-(4-(tert-Butoxycarbonyl)Piperazin-1-Yl)-3-Chloropyridin-4-Yl)Trifluoroborate
CAS No.	1704704-41-5
Molecular Formula	C14H19BClF3KN3O2
Molecular Weight	400.48 g/mol
Synonyms	Potassium (3-Chloro-2-(4-((tert-butoxy)carbonyl)piperazin-1-yl)pyridin-4-yl)trifluoroborate; (2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-3-chloropyridin-4-yl)trifluoroborate potassium salt; Potassium (3-Chloro-2-(4-Boc-piperazin-1-yl)-4-pyridyl)trifluoroborate; Boc-Piperazine-Chloropyridine-Trifluoroborate Potassium Salt; 1704704-41-5; Potassium Organotrifluoroborate, Boc-Piperazine-Chloropyridine-; KF3B-C14H19ClN3O2
EINECS	Contact for details

Quality Control

Our production of Potassium (2-(4-(tert-Butoxycarbonyl)Piperazin-1-Yl)-3-Chloropyridin-4-Yl)Trifluoroborate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical characterization, including NMR (¹H, ¹³C, ¹⁹F, ¹¹B), HPLC for purity assessment, and KF titration for moisture content, ensuring consistency and reliability for critical coupling reactions. Certificates of Analysis (COA) with full spectral data are provided for each lot.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon/nitrogen) when opening to prevent decomposition. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Assay (NMR)	≥90%
Water Content (KF)	≤2.0%
Solubility	Soluble in DMF, DMSO; sparingly soluble in THF, MeOH

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.