Description

Methyl 8-(tert-Butyl)-6-Chloroimidazo[1,2-B]Pyridazine-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate designed for precision synthesis. This compound is critical for research and development in medicinal chemistry, offering a versatile building block for creating novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of novel drug candidates, particularly those targeting specific enzyme pathways.
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• API Development: Integral in the development and scale-up processes for new Active Pharmaceutical Ingredients (APIs) in pre-clinical and clinical stages.
• Oncology Drug Discovery: Serves as a critical intermediate in the synthesis of potential kinase inhibitors and other targeted cancer therapies.
• CNS-Active Compound Synthesis: Employed in the research of new compounds intended to interact with central nervous system receptors.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Used in university and institutional labs for fundamental research in heterocyclic chemistry and drug design methodologies.

Basic Information

Item	Detail
Product Name	Methyl 8-(tert-Butyl)-6-Chloroimidazo[1,2-B]Pyridazine-2-Carboxylate
CAS No.	1690176-75-0
Molecular Formula	C₁₂H₁₄ClN₃O₂
Molecular Weight	267.71 g/mol
Synonyms	Methyl 8-tert-butyl-6-chloroimidazo[1,2-b]pyridazine-2-carboxylate; 6-Chloro-8-(tert-butyl)imidazo[1,2-b]pyridazine-2-carboxylic acid methyl ester; 1690176-75-0; Imidazo[1,2-b]pyridazine-2-carboxylic acid, 6-chloro-8-(1,1-dimethylethyl)-, methyl ester; Methyl 6-chloro-8-(tert-butyl)imidazo[1,2-b]pyridazine-2-carboxylate
EINECS	Contact for details

Quality Control

Every batch of Methyl 8-(tert-Butyl)-6-Chloroimidazo[1,2-B]Pyridazine-2-Carboxylate is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard grade meets high-purity requirements typical for pharmaceutical R&D applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥97% by HPLC), identity confirmation, and impurity profiles is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from incompatible materials. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Any individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.