Description

Tetraethylene Glycol 4-Methylbenzyl Ether Tosylate is a specialized organic intermediate featuring a polyether chain terminated with a tosylate leaving group. This molecular architecture makes it a valuable building block in synthetic organic chemistry, particularly for the controlled introduction of hydrophilic spacer units. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and advanced materials sectors for constructing complex molecules, modifying surfaces, or creating functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring polyethylene glycol (PEG) linkers for solubility or pharmacokinetic modulation.
• Polymer Chemistry: Used as a monomer or chain extender in the production of specialty polyethers, functional polymers, and dendrimers.
• Surface Modification Agent: Employed to graft hydrophilic, non-fouling polyether layers onto materials for biomedical devices or sensor surfaces.
• Ligand and Conjugate Synthesis: Facilitates the attachment of targeting moieties, dyes, or reporter molecules to core structures in bioconjugation and diagnostic reagent development.
• Crosslinking Agent: Acts as a spacer in the formation of hydrogels or crosslinked polymer networks with tailored mesh sizes.
• Chemical Research (R&D): Serves as a versatile reagent for exploring new synthetic methodologies and creating novel chemical entities in academic and industrial laboratories.

Basic Information

Product Name	Tetraethylene Glycol 4-Methylbenzyl Ether Tosylate
CAS No.	1688666-28-5
Molecular Formula	C22H30O8S
Molecular Weight	454.54 g/mol
Synonyms	2-[2-[2-[2-(4-Methylbenzyloxy)ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate; Tetraethylene Glycol Monop-Tolyl Ether p-Toluenesulfonate; PEG4 4-Methylbenzyl Ether Tosylate; 4-Methylbenzyl-TEG-OTs; 4-Methylbenzyl Tetraethylene Glycol Tosylate; p-Tolyl-TEG-OTs; 2,5,8,11-Tetraoxatetradecan-14-yl 4-methylbenzyl ether 4-methylbenzenesulfonate
EINECS	Contact for details

Quality Control

Every batch of Tetraethylene Glycol 4-Methylbenzyl Ether Tosylate is manufactured and tested under a strict quality management system. We ensure identity, purity, and consistency through advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture, which may affect product stability and performance.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.