Description

trans-3-Methyl-4-Aminotetrahydropyran Hydrochloride is a high-purity, advanced pharmaceutical intermediate in its stable salt form. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) and novel chemical entities, offering a defined stereochemistry essential for modern drug development. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in medicinal chemistry, process R&D, and the production of targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel APIs, particularly in central nervous system (CNS) and antiviral research.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic candidates.
• Process Chemistry Development: Serves as a starting material or intermediate in scaling up synthetic routes from laboratory to pilot and commercial scale.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) producing specialized compounds for clients.
• Academic & Industrial Research: Employed in chemical research to explore new reactions and methodologies involving functionalized tetrahydropyran scaffolds.

Basic Information

Product Name	trans-3-Methyl-4-Aminotetrahydropyran Hydrochloride
CAS No.	1682655-57-7
Molecular Formula	C7H16ClNO
Molecular Weight	165.66 g/mol
Synonyms	trans-3-Methyl-4-aminotetrahydropyran HCl; (3R,4S)-3-Methyl-4-aminotetrahydropyran hydrochloride; (3S,4R)-3-Methyl-4-aminotetrahydropyran hydrochloride; 4-Amino-3-methyltetrahydropyran hydrochloride (trans); 3-Methyl-4-aminotetrahydropyran hydrochloride; 4-Amino-3-methyloxane hydrochloride; Tetrahydro-3-methyl-4H-pyran-4-amine hydrochloride
EINECS	Contact for details

Quality Control

Our trans-3-Methyl-4-Aminotetrahydropyran Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D and manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical parameters such as assay, enantiomeric excess, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.