Description

Tos-Peg2-Ch2Co2Tbu CAS NO 1643957-24-7 is a specialized bifunctional PEG linker featuring a tosylate (Tos) leaving group and a tert-butyl ester (CO2tBu) protected carboxylic acid. This compound is a critical intermediate for the controlled synthesis of bioconjugates, enabling the precise attachment of bioactive molecules, dyes, or drugs to various platforms. It is primarily utilized by researchers and process chemists in pharmaceutical development, biotech, and advanced materials science for creating targeted drug delivery systems, diagnostic agents, and functionalized polymers.

Application

• Bioconjugation and ADC Development: Serves as a key heterobifunctional crosslinker for constructing antibody-drug conjugates (ADCs) and protein-polymer conjugates.
• Polymer Functionalization: Used to introduce reactive sites or protected carboxyl groups into PEG-based polymers and hydrogels for subsequent coupling.
• Prodrug Synthesis: Enables the attachment of therapeutic agents via a cleavable PEG spacer, enhancing solubility and pharmacokinetics.
• Diagnostic Reagent Preparation: Facilitates the labeling of peptides, proteins, or nanoparticles with imaging probes or reporter molecules.
• Solid-Phase Peptide Synthesis (SPPS): Acts as a building block or handle for introducing PEG chains into synthetic peptides.
• Surface Modification: Used to functionalize materials and biosensor surfaces with hydrophilic, non-fouling PEG layers.

Basic Information

Product Name	Tos-Peg2-Ch2Co2Tbu
CAS No.	1643957-24-7
Molecular Formula	C20H32O8S
Molecular Weight	432.53 g/mol
Synonyms	2,5,8,11-Tetraoxatetradecan-14-oic acid, 13-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester; tert-Butyl 13-((tosyloxy)acetate)-3,6,9-trioxa-12-azatetradecanoate; PEG2 Tosylate tert-Butyl Ester; Tos-PEG2-CH2COOtBu; 1-tert-Butyl 13-(4-methylbenzenesulfonate) 2,5,8,11-tetraoxatetradecanedioate; Heterobifunctional PEG Linker, Tosylate-PEG2-Acid-tBu ester; α-Tosyl-ω-(tert-butyl ester) PEG2 linker
EINECS	Contact for details

Quality Control

Our Tos-Peg2-Ch2Co2Tbu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports applications in GMP and cGMP environments where traceability and documentation are paramount.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.