Description

tert-Butyl (6-Chloro-3-Methyl-[1,2,4]Triazolo[4,3-B]Pyridazin-8-Yl)Carbamate is a high-purity, advanced pharmaceutical intermediate characterized by its fused triazolopyridazine heterocyclic core. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• API Development: Integral in the process development and scale-up stages for new chemical entities (NCEs), especially those containing the [1,2,4]triazolo[4,3-b]pyridazine moiety.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs for custom synthesis projects and pre-clinical sample production.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery programs.

Basic Information

Product Name	tert-Butyl (6-Chloro-3-Methyl-[1,2,4]Triazolo[4,3-B]Pyridazin-8-Yl)Carbamate
CAS No.	1639116-75-8
Molecular Formula	C11H14ClN5O2
Molecular Weight	283.71 g/mol
Synonyms	Boc-6-Chloro-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-amine; tert-Butyl N-(6-chloro-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl)carbamate; 8-[(tert-Butoxycarbonyl)amino]-6-chloro-3-methyl-[1,2,4]triazolo[4,3-b]pyridazine; 1639116-75-8; Carbamic acid, N-(6-chloro-3-methyl[1,2,4]triazolo[4,3-b]pyridazin-8-yl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl (6-Chloro-3-Methyl-[1,2,4]Triazolo[4,3-B]Pyridazin-8-Yl)Carbamate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques. We support compliance with ICH guidelines for impurities and can provide material meeting custom purity specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Single Maximum Impurity	≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.