Description

trans-3-Methyl-4-Aminotetrahydropyran Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a defined stereochemistry. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. It is primarily sought by pharmaceutical manufacturers and R&D organizations focused on developing novel therapeutic agents, including central nervous system (CNS) drugs and other specialized small-molecule pharmaceuticals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, especially those targeting neurological pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes within drug discovery programs.
• API Synthesis: Serves as a crucial precursor in the commercial-scale production of specific active pharmaceutical ingredients requiring the trans-3-methyl-4-aminotetrahydropyran scaffold.
• Chemical Reference Standard: Employed as an analytical standard for quality control and method development in pharmaceutical analysis.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric reactions to introduce chiral complexity into target molecules.

Basic Information

Product Name	trans-3-Methyl-4-Aminotetrahydropyran Hydrochloride
CAS No.	1638744-60-1
Molecular Formula	C7H16ClNO
Molecular Weight	165.66 g/mol
Synonyms	trans-3-Methyl-4-aminotetrahydropyran HCl; (3R,4S)-3-Methyl-4-aminotetrahydropyran hydrochloride; (3S,4R)-3-Methyl-4-aminotetrahydropyran hydrochloride; 4-Amino-3-methyltetrahydropyran hydrochloride (trans-); 3-Methyl-4-aminotetrahydropyran hydrochloride (trans isomer); Tetrahydro-3-methyl-4H-pyran-4-amine hydrochloride (trans-); 4-Amino-3-methyloxane hydrochloride
EINECS	Contact for details

Quality Control

Our trans-3-Methyl-4-Aminotetrahydropyran Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing identity, purity (by HPLC), chiral excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee (trans isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.