Description

n-Benzyl-3-(trifluoromethyl)oxolan-3-amine is a high-value, fluorinated heterocyclic amine building block of significant interest in advanced organic synthesis. Its molecular architecture, featuring a benzyl-protected amine adjacent to a trifluoromethylated oxolane (tetrahydrofuran) ring, makes it a versatile precursor for constructing complex pharmacophores and agrochemical intermediates. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-infectives, and metabolic diseases.
• Agrochemical Synthesis: Serves as a crucial building block for creating novel herbicides, fungicides, and insecticides, where the trifluoromethyl group often enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs) due to its amine functionality and stereogenic center.
• Material Science Research: Employed in the synthesis of advanced polymers and functional materials where fluorine incorporation can modify surface properties and thermal stability.
• Chemical Biology Probes: Utilized as a scaffold for developing molecular probes and tags to study biological processes and protein interactions.

Basic Information

Product Name	n-Benzyl-3-(trifluoromethyl)oxolan-3-amine
CAS No.	1638269-36-9
Molecular Formula	C12H14F3NO
Molecular Weight	245.24 g/mol
Synonyms	3-(Benzylamino)-3-(trifluoromethyl)tetrahydrofuran; N-Benzyl-3-(trifluoromethyl)tetrahydrofuran-3-amine; 3-(Trifluoromethyl)-3-(benzylamino)oxolane; 3-Benzylamino-3-trifluoromethyltetrahydrofuran; Tetrahydro-3-(benzylamino)-3-(trifluoromethyl)furan; 3-(Benzylamino)-3-(trifluoromethyl)oxolane; N-Benzyl-3-(trifluoromethyl)oxolan-3-amine
EINECS	Contact for details

Quality Control

Our n-Benzyl-3-(trifluoromethyl)oxolan-3-amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization including HPLC for purity, NMR and MS for structural confirmation, and KF titration for moisture content to ensure consistency and reliability for your critical R&D and scale-up processes. Certificates of Analysis (COA) with full analytical data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.