Description

Trifluoroacetic Acid is a highly versatile and potent fluorinated organic acid essential for modern chemical synthesis and analysis. Its unique combination of strong acidity, high volatility, and excellent solvating properties makes it a critical reagent and solvent in demanding industrial and research applications. This product is indispensable for professionals in the pharmaceutical, agrochemical, and specialty chemical sectors, where it serves as a key building block and reaction medium for peptide synthesis, HPLC analysis, and the production of advanced materials.

Application

• Peptide Synthesis & Biopharmaceuticals: As a crucial cleavage and deprotection reagent in solid-phase peptide synthesis (SPPS) and for the purification of synthetic peptides and oligonucleotides.
• Analytical Chemistry (HPLC): A widely used mobile phase modifier in reverse-phase High-Performance Liquid Chromatography (HPLC) for the separation of proteins, peptides, and polar compounds.
• Organic Synthesis & Catalysis: Employed as a strong acid catalyst and solvent in various reactions, including esterifications, rearrangements, and as a precursor for trifluoromethylation reagents.
• Agrochemical & Pharmaceutical Intermediates: A key raw material in the synthesis of active pharmaceutical ingredients (APIs) and advanced crop protection agents that incorporate the trifluoromethyl group.
• Polymer & Material Science: Used in the production and modification of specialty polymers, coatings, and electronic materials.
• Laboratory Reagent & Derivatization Agent: Utilized for sample preparation and derivatization in spectroscopy and chromatography to enhance detection.

Basic Information

Product Name	Trifluoroacetic Acid
CAS No.	1630907-01-5
Molecular Formula	C2HF3O2
Molecular Weight	114.02 g/mol
Synonyms	Trifluoroethanoic Acid; TFA; Perfluoroacetic Acid; 2,2,2-Trifluoroacetic Acid; CF3COOH; Trifluoroacetic Acid Anhydride (common misnomer); Kyselina trifluoroctova; Acide trifluoroacetique
EINECS	Contact for details

Quality Control

Our Trifluoroacetic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Production adheres to current Good Manufacturing Practices (cGMP) where applicable, and the product can be supplied in various grades, including HPLC and peptide synthesis grades, to meet specific application requirements. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles (e.g., water content, non-volatile residue) is provided with each shipment to guarantee compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat and ignition sources. Due to its hygroscopic and highly volatile nature, containers should be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to maintain purity. Recommended storage temperature is 2-8°C (36-46°F) for optimal stability.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms
Assay (GC)	≥ 99.5%
Water Content (KF)	≤ 0.05%
Non-Volatile Residue	≤ 0.005%
Refractive Index (n20D)	1.2850 - 1.2900
Density (20°C)	1.480 - 1.490 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.