Description

trans-2H-Pyran-4-Amine, 3-Fluorotetrahydro-, Hydrochloride is a high-purity fluorinated heterocyclic amine hydrochloride salt, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a structurally defined, functionalized scaffold that is essential for constructing complex molecules with precise stereochemistry. This compound is primarily needed by pharmaceutical R&D and fine chemical manufacturers for applications in medicinal chemistry, particularly in the development of new active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel therapeutic agents, including central nervous system (CNS) drugs and enzyme inhibitors.
• Agrochemical Synthesis: Used in the creation of advanced, fluorinated pesticides and herbicides where the specific stereochemistry influences biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Research: Employed as a probe or building block in the study of biological pathways and protein interactions.
• Material Science: Potential monomer or modifier in the synthesis of specialized polymers with unique properties.

Basic Information

Product Name	trans-2H-Pyran-4-Amine, 3-Fluorotetrahydro-, Hydrochloride
CAS No.	1630906-66-9
Molecular Formula	C5H11ClFNO
Molecular Weight	155.60 g/mol
Synonyms	(3R,4S)-3-Fluorotetrahydro-2H-pyran-4-amine hydrochloride; (3S,4R)-3-Fluorotetrahydro-2H-pyran-4-amine hydrochloride; trans-3-Fluorotetrahydro-2H-pyran-4-amine HCl; 3-Fluorotetrahydropyran-4-amine hydrochloride; 4-Amino-3-fluorotetrahydropyran hydrochloride; 3-Fluoro-4-aminotetrahydropyran HCl; 3-Fluorotetrahydro-2H-pyran-4-amine hydrochloride (trans isomer)
EINECS	Contact for details

Quality Control

Our trans-2H-Pyran-4-Amine, 3-Fluorotetrahydro-, Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to confirm stereochemical purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profile, and physical characteristics. Our quality commitment ensures material suitable for demanding applications in cGMP and research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% de (trans isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.