Description

(3R,4S)-3-Fluorotetrahydro-2H-Pyran-4-Amine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic utility. Its value lies in the precise stereochemistry and the fluorine atom, which are critical for modulating the biological activity, metabolic stability, and physicochemical properties of target drug molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those working on novel small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in medicinal chemistry programs targeting central nervous system (CNS) disorders, infectious diseases, and metabolic conditions.
• Organofluorine Chemistry Research: Serves as a valuable substrate for studying the effects of fluorine substitution in heterocyclic systems and for developing new fluorination methodologies.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the fluorine atom can enhance bioactivity and environmental persistence.
• Ligand and Catalyst Development: The amine functionality and chiral center make it a potential precursor for asymmetric catalysts or chiral ligands used in enantioselective synthesis.
• Peptidomimetics and Bioisosteres: The tetrahydropyran scaffold is a common bioisostere for sugar and peptide moieties, making this compound useful in designing protease inhibitors or GPCR modulators.

Basic Information

Product Name	(3R,4S)-3-Fluorotetrahydro-2H-Pyran-4-Amine Hydrochloride
CAS No.	1630815-55-2
Molecular Formula	C5H11ClFNO
Molecular Weight	155.60 g/mol (Free base: 119.15 g/mol)
Synonyms	(3R,4S)-3-Fluorooxan-4-amine hydrochloride; (3R,4S)-3-Fluorotetrahydro-2H-pyran-4-amine HCl; 4-Amino-3-fluorotetrahydropyran hydrochloride, (3R,4S)-; (3R,4S)-3-Fluoro-4-aminotetrahydropyran hydrochloride; (3R,4S)-4-Amino-3-fluorotetrahydropyran hydrochloride; 1630815-55-2; FC-000003
EINECS	Contact for details

Quality Control

Our (3R,4S)-3-Fluorotetrahydro-2H-Pyran-4-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and identity confirmation by NMR and mass spectrometry, to ensure compliance with exacting standards for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.