Description

(3R,3Ar,5R)-5-((Benzyloxy)Methyl)-3-(Fluoromethyl)-3,3A,4,5-Tetrahydro-7H-Pyrano[3,4-C]Isoxazole is a high-purity, advanced pharmaceutical intermediate characterized by its complex, chiral molecular architecture. This compound is of significant value in modern synthetic organic chemistry, particularly for the development of novel active pharmaceutical ingredients (APIs) and bioactive molecules. It is primarily required by research institutions and pharmaceutical companies engaged in the synthesis of complex heterocyclic compounds, where its specific stereochemistry and functional groups are critical for constructing target molecules with high enantiomeric purity.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the multi-step synthesis of potential drug candidates, especially those targeting the central nervous system or infectious diseases.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities with fluorinated and oxygenated heterocyclic scaffolds.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale, requiring consistent high purity and reliable supply.
• Asymmetric Synthesis: Utilized as a sophisticated synthon in catalytic asymmetric reactions to introduce multiple stereocenters into complex molecular frameworks.
• Contract Research & Manufacturing (CRAM): Supplied to organizations providing custom synthesis and development services for the global pharmaceutical industry.
• Academic Research: Used in university and institutional labs for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	(3R,3Ar,5R)-5-((Benzyloxy)Methyl)-3-(Fluoromethyl)-3,3A,4,5-Tetrahydro-7H-Pyrano[3,4-C]Isoxazole
CAS No.	1621585-45-2
Molecular Formula	C15H18FNO3
Molecular Weight	279.31 g/mol
Synonyms	(3R,3aR,5R)-5-[(Benzyloxy)methyl]-3-(fluoromethyl)-3,3a,4,5-tetrahydro-7H-pyrano[3,4-c]isoxazole; 5-((Benzyloxy)methyl)-3-(fluoromethyl)-3,3a,4,5-tetrahydro-7H-pyrano[3,4-c]isoxazole (stereoisomer); (3R,3aR,5R)-5-(Benzyloxymethyl)-3-(fluoromethyl)-3,3a,4,5-tetrahydro-7H-pyrano[3,4-c]isoxazole; Pyrano[3,4-c]isoxazole derivative CAS 1621585-45-2; Fluoromethyl-pyranoisoxazole intermediate; Benzyl-protected fluorinated pyranoisoxazole
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency critical for pharmaceutical R&D. The material is characterized and released using validated analytical methods including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing all relevant specifications. We support development under cGMP guidelines where required and can provide documentation for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be sensitive to moisture and should be handled under an inert atmosphere for long-term storage to maintain stability. Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.