Description

1-(3,3-Difluorocyclobutyl)Ethan-1-One is a high-purity fluorinated ketone building block of significant interest in advanced organic synthesis. Its unique cyclobutyl core and strategically placed fluorine atoms make it a valuable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in programs targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the difluorocyclobutyl moiety can enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic electronic materials to modify solubility, thermal stability, and electronic properties.
• Chemical Biology Probes: Utilized as a building block for fluorescent tags and molecular probes in diagnostic and imaging applications.

Basic Information

Product Name	1-(3,3-Difluorocyclobutyl)Ethan-1-One
CAS No.	1621223-57-1
Molecular Formula	C6H8F2O
Molecular Weight	134.12 g/mol
Synonyms	1-(3,3-Difluorocyclobutyl)ethanone; 3,3-Difluorocyclobutyl Methyl Ketone; 1-Acetyl-3,3-difluorocyclobutane; 3,3-Difluorocyclobutan-1-yl methyl ketone; Ethanone, 1-(3,3-difluorocyclobutyl)-; DFCMK
EINECS	Contact for details

Quality Control

Our 1-(3,3-Difluorocyclobutyl)Ethan-1-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up processes. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.