Description

5-Chloro-3-(Trifluoromethyl)Pyridazine is a high-value, halogenated heterocyclic building block of significant interest in advanced chemical synthesis. This compound matters for its unique molecular architecture, which combines a pyridazine core with both chloro and trifluoromethyl substituents, offering versatile reactivity for constructing complex molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, particularly where the introduction of fluorine atoms is desired to modulate biological activity, metabolic stability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially for kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the design and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances bioactivity and environmental persistence.
• Material Science Research: Serves as a precursor for the development of specialty chemicals, liquid crystals, and functional materials requiring specific fluorine-containing motifs.
• Cross-Coupling Reactions: The chlorine atom provides an excellent handle for metal-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to form new carbon-carbon and carbon-heteroatom bonds.
• Nucleophilic Aromatic Substitution: The electron-deficient pyridazine ring facilitates nucleophilic substitution reactions, enabling further functionalization.
• Fluorine Chemistry Building Block: Essential for introducing the pharmacologically privileged trifluoromethyl group into target molecules during medicinal chemistry campaigns.

Basic Information

Product Name	5-Chloro-3-(Trifluoromethyl)Pyridazine
CAS No.	1616070-39-3
Molecular Formula	C5H2ClF3N2
Molecular Weight	182.53 g/mol
Synonyms	5-Chloro-3-(trifluoromethyl)pyridazine; 3-Trifluoromethyl-5-chloropyridazine; 5-Chloro-3-trifluoromethylpyridazine; Pyridazine, 5-chloro-3-(trifluoromethyl)-; 1616070-39-3
EINECS	Contact for details

Quality Control

Our 5-Chloro-3-(Trifluoromethyl)Pyridazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP compliance for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 2°C and 8°C for long-term stability. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.