Description

5-Bromo-2-(Tetrahydro-2H-Pyran-4-Yl)Isoindolin-1-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique isoindolinone core fused with a tetrahydropyran moiety. This compound matters for its critical role as a sophisticated building block in the synthesis of novel active pharmaceutical ingredients (APIs), enabling the development of targeted therapies. It is primarily needed by research institutions and pharmaceutical manufacturers focused on medicinal chemistry, particularly in the discovery and process development stages for new drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of complex drug molecules, especially those targeting neurological and oncological pathways.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and safety profiles.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical companies in drug discovery and development programs.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry and developing new synthetic methodologies.

Basic Information

Item	Details
Product Name	5-Bromo-2-(Tetrahydro-2H-Pyran-4-Yl)Isoindolin-1-One
CAS No.	1614234-06-8
Molecular Formula	C₁₃H₁₄BrNO₂
Molecular Weight	296.16 g/mol
Synonyms	5-Bromo-2-(tetrahydro-2H-pyran-4-yl)-2,3-dihydro-1H-isoindol-1-one; 5-Bromo-2-(oxan-4-yl)-2,3-dihydro-1H-isoindol-1-one; 5-Bromo-2-(tetrahydropyran-4-yl)isoindolin-1-one; 5-Bromo-2-(THP-4-yl)isoindolin-1-one; 1614234-06-8; UNII-Not Assigned
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(Tetrahydro-2H-Pyran-4-Yl)Isoindolin-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure compliance with exacting standards for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.