Description

6-Bromo-3-Iodo-Imidazo[1,2-B]Pyridazine is a highly functionalized heterocyclic building block featuring both bromo and iodo substituents on an imidazopyridazine scaffold — enabling sequential, orthogonal cross-coupling reactions. This dual-halogenated compound serves as a critical intermediate in the synthesis of advanced pharmaceuticals, agrochemicals, and functional materials where precise regioselective derivatization is required. It is primarily utilized by medicinal chemistry R&D teams, contract research organizations (CROs), and fine chemical manufacturers engaged in lead optimization and process development.

Application

• Medicinal chemistry: Key scaffold for synthesizing kinase inhibitors and GPCR modulators via Suzuki, Stille, and Buchwald–Hartwig couplings
• Agrochemical R&D: Building block for novel herbicidal and fungicidal candidates with improved metabolic stability
• Organic electronics: Precursor for nitrogen-rich heteroaromatic semiconductors and emissive layers in OLEDs
• Radiopharmaceutical development: Iodine-125/131 labeling site for preclinical imaging probes
• Chemical biology: Synthesis of covalent PROTAC linkers and targeted protein degraders
• Catalyst ligand design: Core structure for bidentate N,N-donor ligands in transition-metal catalysis

Basic Information

Product Name	6-Bromo-3-Iodo-Imidazo[1,2-B]Pyridazine
CAS No.	1609565-17-4
Molecular Formula	C6H3BrIN4
Molecular Weight	322.93 g/mol
Synonyms	6-Bromo-3-iodoimidazo[1,2-b]pyridazine; 6-Bromo-3-iodo-1H-imidazo[1,2-b]pyridazine; Imidazo[1,2-b]pyridazine, 6-bromo-3-iodo-; 6-Bromo-3-iodo-1H-imidazo[1,2-b]pyridazine; CAS 1609565-17-4; NSC 1008260; AKOS030344273; Z1971103178
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches are verified for identity (IR, HPLC retention time match), purity (≥98.5% by HPLC), and halogen content (Br and I quantified by ICP-MS). Testing follows ACS-grade protocols and aligns with ISO 9001-certified manufacturing practices.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C under inert atmosphere (nitrogen or argon) to prevent oxidation. Keep away from moisture and strong oxidizing agents.

Specification

Item	Specification
Appearance	Pale yellow to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Each impurity ≤0.3%; Total impurities ≤1.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm
Water (Karl Fischer)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.