Description

Tos-Peg4-Ch2Co2H is a heterobifunctional polyethylene glycol (PEG) linker featuring a tosylate (Tos) group for nucleophilic substitution and a terminal carboxylic acid (CO2H) for conjugation via amide bond formation. This compound is a critical reagent in bioconjugation and pharmaceutical development, enabling the controlled attachment of molecules, peptides, or proteins to create stable, functionalized constructs. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceuticals, proteomics, and advanced material science for applications such as antibody-drug conjugate (ADC) development and PEGylation.

Application

• Bioconjugation Reagent: For linking drugs, dyes, or other functional molecules to antibodies, proteins, or peptides to create targeted therapeutics like Antibody-Drug Conjugates (ADCs).
• PEGylation Agent: To modify therapeutic proteins or peptides, improving their solubility, stability, and circulation half-life in vivo.
• Crosslinker for Material Science: Used in the synthesis of functionalized hydrogels, surfaces, and polymeric materials requiring specific reactive handles.
• Probe and Diagnostic Development: Serves as a versatile linker for attaching imaging agents or detection tags to biological molecules.
• Intermediate for Specialty Chemicals: A key building block in the multi-step synthesis of complex, value-added chemical entities for research and development.

Basic Information

Product Name	Tos-Peg4-Ch2Co2H
CAS No.	1581248-63-6
Molecular Formula	C20H40O10S
Molecular Weight	472.59 g/mol
Synonyms	2,5,8,11-Tetraoxatridecan-13-oic acid, 13-[[(4-methylphenyl)sulfonyl]oxy]-, 13-(p-Toluenesulfonate); 4,7,10,13-Tetraoxahexadecanoic acid, 16-[(4-methylphenyl)sulfonyl]oxy]-; Tos-PEG4-acid; p-Toluenesulfonate-PEG4-propionic acid; PEG4 Tosylate Acid; α-(p-Toluenesulfonyl)-ω-carboxy tetraethylene glycol; 16-((Tosyloxy)-4,7,10,13-tetraoxahexadecanoic acid
EINECS	Contact for details

Quality Control

Our Tos-Peg4-Ch2Co2H is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.