Description

(E)-n-(2-Hydroxybenzylidene)-3-(Naphthalen-1-Yl)-1H-Pyrazole-5-Carbohydrazide is a high-purity, advanced organic intermediate characterized by its Schiff base and pyrazole-carbohydrazide hybrid structure. This compound matters for its role as a critical building block in the synthesis of novel, high-value chemical entities, offering precise molecular architecture for research and development. It is primarily needed by pharmaceutical R&D laboratories, agrochemical innovators, and specialty chemical manufacturers focused on developing new active ingredients, catalysts, or functional materials. Its defined structure provides a reliable scaffold for creating compounds with targeted biological or chemical activities.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the research and synthesis of novel drug candidates, particularly those targeting specific enzyme inhibition or receptor modulation.
• Agrochemical Research: Used in developing new generations of herbicides, fungicides, or plant growth regulators that require complex heterocyclic cores.
• Coordination Chemistry & Material Science: Acts as a versatile ligand for metal complexes due to its multiple donor sites, applicable in catalysis or the creation of functional materials.
• Organic Synthesis Building Block: Provides a sophisticated scaffold for medicinal and combinatorial chemistry, enabling the exploration of new chemical space.
• Biochemical Research: Utilized in academic and industrial research to study protein-ligand interactions or to develop chemical probes.
• Specialty Chemical Production: Employed in the manufacture of dyes, pigments, or optical materials where specific chromophores are required.

Basic Information

Product Name	(E)-n-(2-Hydroxybenzylidene)-3-(Naphthalen-1-Yl)-1H-Pyrazole-5-Carbohydrazide
CAS No.	1556631-03-8
Molecular Formula	C21H16N4O2
Molecular Weight	356.38 g/mol
Synonyms	(E)-N'-(2-Hydroxybenzylidene)-3-(naphthalen-1-yl)-1H-pyrazole-5-carbohydrazide; 1H-Pyrazole-5-carboxylic acid, 3-(1-naphthalenyl)-, 2-[(2-hydroxyphenyl)methylene]hydrazide, (E)-; 3-(Naphthalen-1-yl)-1H-pyrazole-5-carboxylic acid (2-hydroxybenzylidene)hydrazide; N'-(2-Hydroxybenzylidene)-3-(1-naphthyl)-1H-pyrazole-5-carbohydrazide; (E)-Isomer of Pyrazole-carbohydrazide Schiff Base; Salicylaldehyde 3-(1-Naphthyl)pyrazole-5-carbohydrazone
EINECS	Contact for details

Quality Control

Our (E)-n-(2-Hydroxybenzylidene)-3-(Naphthalen-1-Yl)-1H-Pyrazole-5-Carbohydrazide is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity assay and spectroscopic identification (NMR, IR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality system is designed to support cGMP and ISO standards for advanced intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere if specified. Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.