Description

(2-{2-[2-(Toluene-4-Sulfonyloxy)-Ethoxy]-Ethoxy}-Ethoxy)-Acetic Acid tert-Butyl Ester is a specialized organic intermediate featuring a polyethylene glycol (PEG) spacer and a tosylate leaving group. This compound matters for its role as a versatile building block in the synthesis of complex molecules, particularly in pharmaceutical and bioconjugation chemistry. Researchers and manufacturers in the life sciences sector need it for creating prodrugs, developing targeted drug delivery systems, and modifying biomolecules like peptides and proteins.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and prodrugs, especially those requiring PEGylation for enhanced solubility and pharmacokinetics.
• Bioconjugation Linker: Used to attach drugs, dyes, or other functional moieties to proteins, antibodies, or peptides via its reactive tosylate and ester groups.
• Polymer Chemistry: Serves as a functional monomer or initiator in the synthesis of specialized polymers and dendrimers with tailored properties.
• Prodrug Development: Utilized in designing prodrugs where the tert-butyl ester and PEG chain can be cleaved under specific physiological conditions to release the active drug.
• Chemical Biology Research: A valuable tool for probing biological systems and developing novel diagnostic agents or research reagents.
• Material Science: Intermediate for creating surface modifiers or functional materials with specific hydrophilic characteristics.

Basic Information

Product Name	(2-{2-[2-(Toluene-4-Sulfonyloxy)-Ethoxy]-Ethoxy}-Ethoxy)-Acetic Acid tert-Butyl Ester
CAS No.	1530778-24-5
Molecular Formula	C19H30O8S
Molecular Weight	418.50 g/mol
Synonyms	2-[2-[2-(4-Methylbenzenesulfonyloxy)ethoxy]ethoxy]ethoxyacetic acid tert-butyl ester; tert-Butyl 2-[2-[2-(2-{[(4-methylphenyl)sulfonyl]oxy}ethoxy)ethoxy]ethoxy]acetate; PEG3-tosylate tert-butyl ester; Triethylene glycol monotosylate tert-butyl acetate; TBTA-PEG3-OTs; 4-Methylbenzenesulfonic acid 2-[2-(2-{2-[(tert-butoxycarbonyl)methoxy]ethoxy}ethoxy)ethoxy]ethyl ester
EINECS	Contact for details

Quality Control

Our (2-{2-[2-(Toluene-4-Sulfonyloxy)-Ethoxy]-Ethoxy}-Ethoxy)-Acetic Acid tert-Butyl Ester undergoes rigorous quality testing to ensure compliance with industry standards for high-purity intermediates. We implement strict analytical protocols, including HPLC, NMR, and mass spectrometry, to verify identity, purity, and consistency across batches. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive (store away from light) and should be kept under inert conditions if long-term storage is required. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.