Description

trans-5-(Benzyloxyamino)Piperidine-2-Carboxylic Acid CAS NO 1501980-29-5 is a high-purity, non-natural amino acid derivative featuring a unique piperidine scaffold with a benzyloxyamino substituent. This compound serves as a critical chiral building block and advanced pharmaceutical intermediate for the synthesis of complex bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for the development of protease inhibitors, peptidomimetics, and other therapeutic agents targeting the central nervous system and metabolic diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new chemical entities (NCEs), especially for protease inhibitors and enzyme modulators.
• Medicinal Chemistry Research: Used as a constrained amino acid analog to explore structure-activity relationships (SAR) and improve the metabolic stability and bioavailability of peptide-based drug candidates.
• Peptidomimetic Synthesis: Integral for constructing peptidomimetic scaffolds that mimic natural peptides but with enhanced drug-like properties.
• Chemical Biology Probes: Serves as a building block for creating activity-based probes (ABPs) or labeled compounds to study enzyme function and mechanism.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of active pharmaceutical ingredients (APIs) at various scales.
• Academic Research: Employed in university and institutional labs for synthetic methodology development and exploring novel heterocyclic chemistry.

Basic Information

Item	Detail
Product Name	trans-5-(Benzyloxyamino)Piperidine-2-Carboxylic Acid
CAS No.	1501980-29-5
Molecular Formula	C14H20N2O3
Molecular Weight	264.32 g/mol
Synonyms	(2R,5S)-5-[(Benzyloxy)amino]piperidine-2-carboxylic acid; (2R,5S)-5-(Benzyloxyamino)piperidine-2-carboxylic acid; trans-5-(O-Benzylhydroxyamino)piperidine-2-carboxylic acid; 5-(Benzyloxyamino)piperidine-2-carboxylic acid (trans isomer); BOC Sciences Brand Name: BLD-1501980; A piperidine carboxylic acid derivative; Benzyloxyamino-substituted piperidine
EINECS	Contact for details

Quality Control

Every batch of trans-5-(Benzyloxyamino)Piperidine-2-Carboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting identity, purity, and impurity profiles. Our quality protocols are designed to support regulatory filings, and we can provide material suitable for use under cGMP guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
trans-Isomer Content (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.