Description

((2R,3R,4R)-3-(Benzoyloxy)-4-Chloro-4-Methyl-5-Oxotetrahydrofuran-2-Yl)Methyl Benzoate is a high-purity, stereochemically defined chiral building block and synthetic intermediate of significant interest in advanced organic synthesis. This compound matters for its precise molecular architecture, which is critical for constructing complex molecules with defined stereocenters, a key requirement in modern pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for applications in asymmetric synthesis and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for complex target molecules.
• Asymmetric Synthesis: Used as a building block in stereoselective reactions to introduce specific chiral configurations into larger molecular frameworks.
• Process Chemistry: Employed in route scouting and scale-up studies for the efficient production of candidate drugs.
• Agrochemical Research: Acts as a precursor in the synthesis of novel herbicides, fungicides, or insecticides where specific stereochemistry impacts biological activity.
• Academic Research: Utilized in university and institutional labs for methodological development in organic and medicinal chemistry.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	((2R,3R,4R)-3-(Benzoyloxy)-4-Chloro-4-Methyl-5-Oxotetrahydrofuran-2-Yl)Methyl Benzoate
CAS No.	1496551-65-5
Molecular Formula	C21H19ClO6
Molecular Weight	402.82 g/mol
Synonyms	(2R,3R,4R)-3-(Benzoyloxy)-4-chloro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate; Methyl (2R,3R,4R)-3-(benzoyloxy)-4-chloro-4-methyl-5-oxotetrahydrofuran-2-carboxylate (related isomer); 4-Chloro-4-methyl-5-oxotetrahydrofuran-2,3-diyl dibenzoate (stereospecific); Chiral tetrahydrofuran derivative; Benzoyl-protected chloromethyl tetrahydrofuranone; 1496551-65-5; CAS 1496551-65-5
EINECS	Contact for details

Quality Control

Our ((2R,3R,4R)-3-(Benzoyloxy)-4-Chloro-4-Methyl-5-Oxotetrahydrofuran-2-Yl)Methyl Benzoate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure high chemical and stereochemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light). Keep container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.