Description

tert-Butyl 2-(4-(4-chlorophenyl)-5-methoxy-1-((2-methyl-6-(trifluoromethyl)pyridin-3-yl)methyl)-6-oxo-1,6-dihydropyridazin-3-yl)hydrazinecarboxylate is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) intermediate of significant commercial and research interest. This compound is a critical building block in the synthesis of next-generation antiviral pharmaceuticals, offering a sophisticated chemical scaffold for drug discovery. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing treatments for viral infections.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the production of novel non-nucleoside reverse transcriptase inhibitors (NNRTIs) for antiviral therapies.
• Antiviral Drug Discovery: Core scaffold for medicinal chemistry programs targeting HIV and other retroviral infections.
• Biochemical Research: Used as a reference standard or probe compound in virology and enzymology studies to understand viral replication mechanisms.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up synthesis under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for investigating structure-activity relationships (SAR) of dihydropyridazine derivatives.
• Process Chemistry Development: Serves as a model compound for optimizing synthetic routes, purification methods, and analytical techniques for complex heterocycles.

Basic Information

Product Name	tert-Butyl 2-(4-(4-chlorophenyl)-5-methoxy-1-((2-methyl-6-(trifluoromethyl)pyridin-3-yl)methyl)-6-oxo-1,6-dihydropyridazin-3-yl)hydrazinecarboxylate
CAS No.	1494218-32-4
Molecular Formula	C24H25ClF3N5O4
Molecular Weight	539.94 g/mol
Synonyms	Boc-Protected Dihydropyridazine Hydrazine Derivative; tert-Butyl (4-(4-chlorophenyl)-5-methoxy-1-((2-methyl-6-(trifluoromethyl)pyridin-3-yl)methyl)-6-oxo-1,6-dihydropyridazin-3-yl)carbazate; NNRTI Intermediate 1494218-32-4; 1,6-Dihydropyridazine-3-carboxylic acid, 4-(4-chlorophenyl)-5-methoxy-1-[[2-methyl-6-(trifluoromethyl)-3-pyridinyl]methyl]-6-oxo-, 2-(1,1-dimethylethyl) hydrazide; Carbamic acid, N-[4-(4-chlorophenyl)-5-methoxy-1-[[2-methyl-6-(trifluoromethyl)-3-pyridinyl]methyl]-6-oxo-1,6-dihydro-3-pyridazinyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(4-(4-chlorophenyl)-5-methoxy-1-((2-methyl-6-(trifluoromethyl)pyridin-3-yl)methyl)-6-oxo-1,6-dihydropyridazin-3-yl)hydrazinecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to ISO 9001 standards, and we can support development projects requiring ICH stability guidelines or cGMP compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.