Description

(S)-n-Benzyl-2-(3-(3,5-Bis(trifluoromethyl)phenyl)thioureido)-3,3-dimethylbutanamide is a high-purity, chiral thiourea derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a critical building block or intermediate for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors seeking to incorporate its unique trifluoromethylated and thiourea motifs into complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new drug candidates, particularly in protease inhibitor and receptor antagonist programs.
• Catalyst or Ligand Precursor: Potential use in the synthesis of organocatalysts or metal-complexing ligands for asymmetric synthesis.
• Agrochemical Research: Intermediate for developing novel pesticides or herbicides leveraging the bioactivity of the thiourea and trifluoromethyl groups.
• Material Science: Building block for advanced polymers or functional materials requiring specific fluorine-containing units.
• Chemical Biology Probe: Used in medicinal chemistry to study protein-ligand interactions and structure-activity relationships (SAR).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.

Basic Information

Product Name	(S)-n-Benzyl-2-(3-(3,5-Bis(trifluoromethyl)phenyl)thioureido)-3,3-dimethylbutanamide
CAS No.	1490388-03-8
Molecular Formula	C23H25F6N3OS
Molecular Weight	505.52 g/mol
Synonyms	(S)-N-Benzyl-2-[3-[3,5-bis(trifluoromethyl)phenyl]thioureido]-3,3-dimethylbutyramide; (S)-2-(3-(3,5-Bis(trifluoromethyl)phenyl)thioureido)-N-benzyl-3,3-dimethylbutanamide; BDBT; Benzyl-3,5-bis(trifluoromethyl)phenylthiourea-valine derivative; (S)-tert-Leucine derived thiourea benzylamide; N-((S)-1-Benzylamino-3,3-dimethyl-1-oxobutan-2-yl)-N'-(3,5-bis(trifluoromethyl)phenyl)thiourea
EINECS	Contact for details

Quality Control

Our (S)-n-Benzyl-2-(3-(3,5-Bis(trifluoromethyl)phenyl)thioureido)-3,3-dimethylbutanamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure compliance with exacting R&D and cGMP-grade standards where applicable. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.