Description

3-(Difluoromethyl)Cyclobutanone is a specialized fluorinated organic building block of significant interest in advanced chemical synthesis. Its unique structure, featuring a cyclobutanone ring and a difluoromethyl group, makes it a valuable precursor for introducing fluorinated motifs into target molecules, which can dramatically alter their physical, chemical, and biological properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting metabolic stability and bioavailability enhancement through fluorine incorporation.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides where the difluoromethyl group can improve lipophilicity and biological activity.
• Advanced Material Precursor: Serves as a building block for synthesizing fluorinated polymers or liquid crystals with tailored properties such as chemical resistance, thermal stability, or specific optical characteristics.
• Organic Synthesis Reagent: Employed in academic and industrial R&D for constructing complex, fluorinated organic molecules via reactions like nucleophilic addition or ring-expansion transformations.
• Fluorine Chemistry Research: An essential compound for studying the effects of gem-difluorination on the reactivity and conformation of strained ring systems.

Basic Information

Product Name	3-(Difluoromethyl)Cyclobutanone
CAS No.	1461713-56-3
Molecular Formula	C5H6F2O
Molecular Weight	120.10 g/mol
Synonyms	3-(Difluoromethyl)cyclobutan-1-one; Cyclobutanone, 3-(difluoromethyl)-; 3-Difluoromethylcyclobutanone; 1-(Difluoromethyl)cyclobutan-3-one; Difluoromethyl cyclobutanone
EINECS	Contact for details

Quality Control

Every batch of 3-(Difluoromethyl)Cyclobutanone is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and process chemistry. A detailed Certificate of Analysis (COA) specifying purity, identity, and impurity profiles by techniques such as GC, HPLC, NMR, and MS is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place at controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and potential concentration changes. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.