Description

tert-Butyl ((2S,3S)-2-(2,5-Difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate is a high-purity chiral building block featuring a protected amine and a lactone moiety. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis of complex, biologically active molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing novel drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs).
• Protease Inhibitor Development: Serves as a core scaffold for designing inhibitors of serine and cysteine proteases.
• CNS Drug Discovery: Used in research programs targeting neurological conditions due to its ability to cross the blood-brain barrier.
• Peptidomimetic Chemistry: Employed to create stable, drug-like analogs of peptide structures.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in catalytic asymmetric transformations.
• Process Chemistry & Scale-Up: Supports the development of robust and scalable manufacturing routes for candidate drugs.

Basic Information

Product Name	tert-Butyl ((2S,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate
CAS No.	1456616-44-6
Molecular Formula	C16H19F2NO4
Molecular Weight	327.33 g/mol
Synonyms	(3S,4S)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-(2,5-difluorophenyl)tetrahydro-2H-pyran-2-one; tert-Butyl N-[(3S,4S)-3-(2,5-difluorophenyl)-2-oxo-4-tetrahydropyranyl]carbamate; (2S,3S)-3-[(tert-Butoxycarbonyl)amino]-2-(2,5-difluorophenyl)dihydro-2H-pyran-5(4H)-one; Boc-(3S,4S)-Amino(2,5-difluorophenyl)dihydropyranone; 1456616-44-6; (3S,4S)-Boc-Amino-3-(2,5-difluorophenyl)dihydro-2H-pyran-2-one
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized and controlled using advanced analytical techniques to guarantee identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results for chiral purity, chemical purity, and specified impurities. We adhere to cGMP principles where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and may be sensitive to fluoride/strong alkali conditions. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.