Description

tert-Butyl ((2R,3R)-2-(2,5-Difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate is a high-purity, stereochemically defined chiral building block of significant importance in advanced pharmaceutical synthesis. Its value lies in its role as a key intermediate for constructing complex molecules, particularly in the development of new active pharmaceutical ingredients (APIs). This compound is essential for research and production chemists in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of novel therapeutic agents, particularly in medicinal chemistry programs.
• API Development: Used in the research and scale-up synthesis of potential Active Pharmaceutical Ingredients (APIs), especially those targeting central nervous system (CNS) and metabolic disorders.
• Asymmetric Synthesis: Serves as a valuable precursor in stereoselective reactions to introduce complex molecular architectures with defined chirality.
• Process Chemistry: Employed in route scouting and optimization for the commercial-scale manufacturing of drug candidates.
• Chemical Biology Research: Utilized as a probe or precursor in the synthesis of compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A key material for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke synthesis services to the pharma industry.

Basic Information

Item	Details
Product Name	tert-Butyl ((2R,3R)-2-(2,5-Difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate
CAS No.	1456616-43-5
Molecular Formula	C16H19F2NO4
Molecular Weight	327.33 g/mol
Synonyms	Boc-Protected (2R,3R)-2-(2,5-Difluorophenyl)dihydro-5H-pyran-3-amine-5-one; (2R,3R)-3-((tert-Butoxycarbonyl)amino)-2-(2,5-difluorophenyl)tetrahydro-2H-pyran-5-one; tert-Butyl N-[(3R,4R)-4-(2,5-difluorophenyl)-6-oxooxan-3-yl]carbamate; (3R,4R)-3-[(tert-Butoxycarbonyl)amino]-4-(2,5-difluorophenyl)tetrahydro-2H-pyran-6-one; BOC-(2R,3R)-2-(2,5-Difluorophenyl)-5-oxotetrahydro-2H-pyran-3-amine; CAS 1456616-43-5
EINECS	Contact for details

Quality Control

Our tert-Butyl ((2R,3R)-2-(2,5-Difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure high chemical and chiral purity, meeting the stringent requirements for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed specifications for identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.