Description

2-Chloro-6-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate is a high-value organosilicon building block and triflate ester, essential for advanced organic synthesis. Its core value lies in its dual functionality, serving as a versatile electrophile for cross-coupling reactions and a robust protecting group precursor. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing aryl groups via Suzuki-Miyaura and other palladium-catalyzed cross-couplings.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the chlorophenyl and silyl groups impart specific biological activity and stability.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized phosphine ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the creation of organic semiconductors, liquid crystals, and polymers with tailored electronic and thermal properties.
• Chemical Biology Probes: Useful for the site-specific modification of biomolecules and the development of molecular probes due to its selective reactivity.
• Scale-Up Process Chemistry: A reliable reagent for pilot plant and commercial-scale manufacturing where consistent quality and reactivity are paramount.

Basic Information

Product Name	2-Chloro-6-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate
CAS No.	1449472-59-6
Molecular Formula	C10H12ClF3O3SSi
Molecular Weight	332.80 g/mol
Synonyms	2-Chloro-6-(trimethylsilyl)phenyl triflate; (2-Chloro-6-(trimethylsilyl)phenyl) trifluoromethanesulfonate; 2-Chloro-6-trimethylsilylphenyl trifluoromethanesulfonate; Trifluoromethanesulfonic acid 2-chloro-6-(trimethylsilyl)phenyl ester; 2-Chloro-6-(TMS)phenyl Triflate; OTf Ester of 2-Chloro-6-(trimethylsilyl)phenol
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-6-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate is manufactured and tested under strict quality management systems. We guarantee high chemical purity and lot-to-lot consistency suitable for demanding synthetic applications. Comprehensive analytical testing, including NMR, HPLC, and GC, is performed. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.