Description

n-[(1S,2S)-2-[[[[(1R,2R)-2-(Dimethylamino)Cyclohexyl]Amino]Thioxomethyl]Amino]-1,2-Diphenylet is a sophisticated chiral thiourea derivative, a class of compounds renowned for their utility as organocatalysts and ligands in asymmetric synthesis. Its precise stereochemistry and functional groups make it a valuable building block for constructing complex molecular architectures with high enantioselectivity. This compound is essential for research and development chemists in the pharmaceutical and fine chemical industries seeking to develop novel synthetic pathways and active pharmaceutical ingredients (APIs).

Application

• Asymmetric Organocatalysis: Serves as a chiral catalyst or catalyst precursor for enantioselective carbon-carbon and carbon-heteroatom bond-forming reactions.
• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Chiral Ligand Synthesis: Used as a precursor for developing novel chiral ligands for transition metal catalysis.
• Academic & Industrial R&D: A critical reagent for methodological development in synthetic organic chemistry laboratories.
• Fine Chemical Production: Enables the production of high-value, enantiomerically pure specialty chemicals and flavors/fragrances.

Basic Information

Item	Detail
Product Name	n-[(1S,2S)-2-[[[[(1R,2R)-2-(Dimethylamino)Cyclohexyl]Amino]Thioxomethyl]Amino]-1,2-Diphenylet
CAS No.	1448608-06-7
Molecular Formula	C29H34N4S
Molecular Weight	470.67 g/mol
Synonyms	(1S,2S)-N-((((1R,2R)-2-(Dimethylamino)cyclohexyl)carbamothioyl)amino)-1,2-diphenylethan-1-amine; Chiral Thiourea Catalyst; (S,S)-1,2-Diphenylethylenediamine-derived thiourea; (R,R)-DMACH Thiourea Derivative; Asymmetric Thiourea Organocatalyst; CAS 1448608-06-7
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, chiral HPLC, and NMR to confirm identity, enantiomeric excess (ee), and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); ensure the container is sealed under an inert atmosphere after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.