Description

(S)-1-(3,5-Bis(Trifluoromethyl)Phenyl)-3-(1-Phenylethyl)Thiourea is a high-value chiral thiourea derivative, a key building block in advanced organic synthesis. Its molecular structure, featuring electron-withdrawing trifluoromethyl groups and a stereogenic center, makes it an exceptional catalyst and ligand for asymmetric transformations. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with high enantiomeric purity.

Application

• Asymmetric Organocatalysis: Serves as a highly effective hydrogen-bond donor catalyst for enantioselective reactions, including Michael additions, Mannich reactions, and acylations.
• Pharmaceutical Intermediate: A critical chiral scaffold in the synthesis of potential drug candidates, particularly for central nervous system (CNS) and antiviral targets.
• Chiral Ligand Synthesis: Used as a precursor for developing novel ligands in transition metal catalysis for producing enantiomerically pure compounds.
• Agrochemical Research: Employed in the development of new, more selective herbicides and pesticides with improved environmental profiles.
• Material Science: Investigated for the creation of chiral functional materials and sensors due to its specific molecular recognition properties.
• Academic & Process R&D: A valuable tool for methodological development in university and industrial R&D laboratories focused on stereocontrolled synthesis.

Basic Information

Product Name	(S)-1-(3,5-Bis(Trifluoromethyl)Phenyl)-3-(1-Phenylethyl)Thiourea
CAS No.	1445582-60-4
Molecular Formula	C₁₇H₁₄F₆N₂S
Molecular Weight	392.36 g/mol
Synonyms	(S)-1-[3,5-Bis(trifluoromethyl)phenyl]-3-(1-phenylethyl)thiourea; (S)-1-(3,5-Bis(trifluoromethyl)phenyl)-3-(α-methylbenzyl)thiourea; (S)-3,5-Bis(trifluoromethyl)phenyl(1-phenylethyl)thiourea; (S)-TU; (S)-Thiourea Catalyst; (S)-Chiral Thiourea Organocatalyst; (S)-1-Phenylethyl-3-(3,5-bis(trifluoromethyl)phenyl)thiourea
EINECS	Contact for details

Quality Control

Our production of (S)-1-(3,5-Bis(Trifluoromethyl)Phenyl)-3-(1-Phenylethyl)Thiourea adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric excess (ee). Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as chiral purity, chemical purity, and identity confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; ensure the container is kept in a dry environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.