Description

6-Chloro-3-Iodo-1H-Cinnolin-4-One is a halogenated cinnolinone derivative, a high-value heterocyclic building block of significant interest in advanced organic synthesis. Its core structure, featuring both chloro and iodo substituents, makes it a versatile and reactive intermediate for constructing complex molecular architectures. This compound is primarily utilized by pharmaceutical and agrochemical research organizations for the development of novel active ingredients, including potential kinase inhibitors and other biologically relevant molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology and CNS research.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators.
• Chemical Biology Probe Synthesis: Serves as a scaffold for creating molecular probes to study enzyme function and biological pathways.
• Material Science: Potential building block for organic electronic materials and advanced polymers.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for palladium-catalyzed reactions (e.g., Suzuki, Sonogashira) to introduce complex substituents.
• Nucleophilic Aromatic Substitution: The chlorine atom allows for further functionalization via substitution reactions.

Basic Information

Product Name	6-Chloro-3-Iodo-1H-Cinnolin-4-One
CAS No.	1443292-33-8
Molecular Formula	C8H4ClIN2O
Molecular Weight	306.49 g/mol
Synonyms	6-Chloro-3-iodo-1H-cinnolin-4-one; 6-Chloro-3-iodocinnolin-4(1H)-one; 4(1H)-Cinnolinone, 6-chloro-3-iodo-; 3-Iodo-6-chloro-1H-cinnolin-4-one; 6-Chloro-3-iodo-4-cinnolinone; 1H-Cinnolin-4-one, 6-chloro-3-iodo-
EINECS	Contact for details

Quality Control

Every batch of 6-Chloro-3-Iodo-1H-Cinnolin-4-One is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our quality commitment supports compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is light-sensitive (store away from light) and should be handled under an inert atmosphere for long-term stability. Keep away from strong acids/bases and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.