Description

Tco-Pnb Ester CAS NO 1438415-89-4 is a specialized, high-purity chemical intermediate designed for advanced organic synthesis. This compound is valued for its role as a protected amino acid derivative, offering precise control in complex peptide and small molecule construction. It is an essential building block for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require reliable, high-quality intermediates for critical development and production processes.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs) and peptide-based therapeutics.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected amino acid derivative, facilitating the controlled elongation of peptide chains.
• Protecting Group Chemistry: Serves as a reagent where the Tco (trimethylsilylethoxycarbonyl) and Pnb (p-nitrobenzyl) groups are employed for the orthogonal protection of amine and carboxylic acid functionalities, respectively.
• Bioconjugation: Applicable in the development of antibody-drug conjugates (ADCs) and other bioconjugates requiring specific, cleavable linkers.
• Chemical Biology Research: A valuable tool for probing biological systems and developing chemical probes where selective deprotection is required.
• Process Development: Employed in scale-up and optimization of synthetic routes for complex organic molecules in R&D and pilot plant settings.

Basic Information

Product Name	Tco-Pnb Ester
CAS No.	1438415-89-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(2,5-Dioxopyrrolidin-1-yl) (4-nitrophenyl) carbonate; 4-Nitrophenyl (2,5-dioxopyrrolidin-1-yl) carbonate; Tco-PNB ester; TCO-PNB active ester; TCO-PNB carbonate; TCO-PNB carbonate, active ester; TCO-PNB carbonate, NHS ester; TCO-PNB-NHS ester
EINECS	Contact for details

Quality Control

Every batch of Tco-Pnb Ester is manufactured and tested under strict quality management systems to ensure consistency and reliability for your critical applications. Our products undergo rigorous quality testing, including advanced chromatographic analysis, to ensure compliance with exacting industry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a desiccated environment to minimize exposure to moisture. Handle and store in accordance with good laboratory/chemical hygiene practices.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.