Description

4-(4-Tetrahydropyranyl)Iodobenzene is a high-purity, advanced organic intermediate featuring a tetrahydropyranyl-protected aromatic iodide functional group. This compound is critical for facilitating complex cross-coupling reactions, such as Suzuki and Negishi couplings, enabling the precise construction of sophisticated molecular architectures. It is an essential building block for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for constructing complex biaryl structures.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides requiring specific aromatic frameworks.
• Material Science Research: Serves as a monomer or building block for creating novel organic electronic materials, liquid crystals, and polymers.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura and Negishi cross-coupling reactions to form carbon-carbon bonds.
• Chemical Synthesis & Process Development: Utilized in process chemistry for scaling up the production of complex organic molecules in R&D and pilot plants.
• Ligand and Catalyst Development: Acts as a starting material for synthesizing specialized ligands and organometallic catalysts.

Basic Information

Product Name	4-(4-Tetrahydropyranyl)Iodobenzene
CAS No.	1434128-30-9
Molecular Formula	C11H13IO
Molecular Weight	288.13 g/mol
Synonyms	4-(Tetrahydro-2H-pyran-4-yl)iodobenzene; 1-Iodo-4-(tetrahydro-2H-pyran-4-yl)benzene; 4-(4-Iodophenyl)tetrahydro-2H-pyran; 4-(Tetrahydro-2H-pyran-4-yl)phenyl iodide; 4-(4-THP)Iodobenzene; THP-Protected 4-Iodobenzene; 4-Iodophenyl tetrahydropyranyl ether (common misnomer for the C-linked variant); Benzene, 1-iodo-4-(tetrahydro-2H-pyran-4-yl)-
EINECS	Contact for details

Quality Control

Our 4-(4-Tetrahydropyranyl)Iodobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to guarantee consistency and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.