Description

1-(3-Bromophenyl)-3-Hydroxycyclobutane-1-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique cyclobutane carboxylic acid scaffold substituted with a bromophenyl group. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting therapeutic areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel small-molecule drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs.
• API Synthesis: Serves as a crucial precursor in multi-step synthetic routes for complex target molecules.
• Chemical Biology Probes: Employed in the design and synthesis of chemical probes for target validation and mechanistic studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials and niche APIs.
• Academic Research: Used in university and institutional labs for methodological development and novel heterocyclic chemistry.

Basic Information

Product Name	1-(3-Bromophenyl)-3-Hydroxycyclobutane-1-Carboxylic Acid
CAS No.	1432058-38-2
Molecular Formula	C11H11BrO3
Molecular Weight	271.11 g/mol
Synonyms	3-Hydroxy-1-(3-bromophenyl)cyclobutane-1-carboxylic acid; 1-(3-Bromophenyl)-3-hydroxycyclobutane carboxylic acid; 3-Hydroxy-1-(m-bromophenyl)cyclobutane-1-carboxylic acid; 1432058-38-2; Cyclobutane-1-carboxylic acid, 1-(3-bromophenyl)-3-hydroxy-; 1-(3-Bromophenyl)-3-hydroxy-1-cyclobutanecarboxylic acid
EINECS	Contact for details

Quality Control

Our 1-(3-Bromophenyl)-3-Hydroxycyclobutane-1-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP compliance for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.