Description

2-Chloro-5-(Pentafluorosulfur)Benzamide is a high-value, fluorinated aromatic building block of significant interest in advanced chemical synthesis. Its core value lies in the unique combination of the benzamide pharmacophore with the highly electronegative and lipophilic pentafluorosulfur (SF5) group, which can dramatically alter the physicochemical properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients with potentially enhanced metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) targets, oncology, and anti-infectives, where the SF5 group can improve pharmacokinetic profiles.
• Agrochemical Research: Used in developing next-generation herbicides, fungicides, and insecticides, leveraging the SF5 moiety to enhance lipophilicity and environmental stability of active compounds.
• Material Science: Acts as a specialty monomer or additive in the research of advanced polymers, liquid crystals, and electronic materials, where fluorine content is prized for thermal and chemical resistance.
• Chemical Biology Probe Development: Utilized as a building block for creating labeled compounds or probes to study biological pathways and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring sophisticated fluorinated chemistry.

Basic Information

Product Name	2-Chloro-5-(Pentafluorosulfur)Benzamide
CAS No.	1431329-71-3
Molecular Formula	C7H3ClF5NOS
Molecular Weight	279.61 g/mol
Synonyms	2-Chloro-5-(pentafluoro-λ6-sulfanyl)benzamide; Benzamide, 2-chloro-5-(pentafluorosulfur)-; 2-Chloro-5-(SF5)benzamide; 5-(Pentafluorosulfanyl)-2-chlorobenzamide; 2-Chloro-5-pentafluorosulfanylbenzamide; 1431329-71-3; SF5-Benzamide derivative
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-(Pentafluorosulfur)Benzamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC-MS for residual solvent analysis, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and/or hygroscopic; handling under an inert atmosphere is recommended for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.