Description

Potassium (1-(tert-Butoxycarbonyl)azetidin-3-yl)trifluoroborate is a high-value organotrifluoroborate reagent, a protected form of the versatile 3-boronic acid azetidine scaffold. This compound is critical for enabling robust and selective cross-coupling reactions, particularly in complex molecule synthesis where stability and functional group tolerance are paramount. It is an essential building block for medicinal chemists and process R&D teams in the pharmaceutical and agrochemical industries, facilitating the efficient construction of novel azetidine-containing compounds.

Application

• Suzuki-Miyaura Cross-Coupling: A key reagent for introducing the valuable azetidine ring into complex molecular architectures under mild conditions.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas.
• Medicinal Chemistry & Drug Discovery: Used extensively in lead optimization and library synthesis to explore structure-activity relationships (SAR) around the azetidine pharmacophore.
• Agrochemical Synthesis: Employed in the development of novel crop protection agents and herbicides.
• Material Science Research: Potential utility in creating novel polymers or ligands with specific steric and electronic properties.
• Peptidomimetics: The azetidine ring is a valuable bioisostere for peptide bonds or other cyclic structures in drug design.

Basic Information

Product Name	Potassium (1-(tert-Butoxycarbonyl)azetidin-3-yl)trifluoroborate
CAS No.	1430219-73-0
Molecular Formula	C8H14BF3KNO2
Molecular Weight	257.11 g/mol
Synonyms	Potassium 1-Boc-3-azetidinyltrifluoroborate; 1-N-Boc-3-Azetidineboronic Acid Potassium Trifluoroborate Salt; 1-(tert-Butoxycarbonyl)-3-(trifluoroboranyl)azetidine Potassium Salt; 3-Trifluoroboratomethyl-1-Boc-azetidine Potassium Salt; Azetidine-3-boronic acid, 1-[(1,1-dimethylethoxy)carbonyl]-, potassium trifluoroborate(1-); Potassium Trifluoro(1-((tert-butoxycarbonyl)azetidin-3-yl))borate; 1-Boc-3-azetidine potassium trifluoroborate; Potassium (1-Boc-azetidin-3-yl)trifluoroborate
EINECS	Contact for details

Quality Control

Our Potassium (1-(tert-Butoxycarbonyl)azetidin-3-yl)trifluoroborate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including NMR (1H, 13C, 19F, 11B), HPLC for purity, and KF titration for moisture content, to ensure it meets the high standards required for sensitive cross-coupling chemistry. A comprehensive Certificate of Analysis (COA) is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (argon or nitrogen) due to its hygroscopic and potentially air/moisture-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline or powder solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Anhydrous Basis)
Water Content (KF)	≤1.0%
19F NMR Purity	Conforms
11B NMR Purity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.